Yale Physical Engineering Biology - transformative research through collaboration

The Center for Genomics and Proteomics is a focal point for the research and teaching of genomics, small molecule screening, proteomics, ribonomics and bioinformatics, including the areas of chemical genomics, comparative genomics, structural genomics, technology development and bioengineering.

The Center includes a nanotechnology laboratory that contains an E-beam lithography exposure tool for writing images with sub-100 nm features and an SPM machine for imaging samples with atomic resolution.

The Center houses a 2600 sq-ft class 100 clean room that contains equipment for solid state device fabrication, including facilities for photolithography, wet chemical etching, oxidation, diffusion, thermal evaporation, sputtering, reactive ion etching, chemical vapor deposition, and other thin film processes.

The Academic Media and Technology group at Yale provides support for high performance computing that includes several large parallel computing clusters, courses and other resources for the development and optimization of parallel computer codes, and cluster administrative support for all IGPPEB faculty. The newest clusters, Bulldog J and Bulldog K, have 1024 and 500 high-speed processors, respectively. Additional computing resources are available from the Center for High Performance Computing in Biology and Biomedicine.

The newly established Richards Center for Molecular Biophysics will provide support for students, postdocs and faculty who use a variety of biophysical methods to characterize the structure and interactions of biological macromolecules and will include instrumentation for x-ray crystallography, solution spectroscopies such as CD, fluorescence and NMR, ultracentrifugation, mass spectroscopy, surface plasmon resonance and robotics for automated cloning and protein purification. Three full-time Ph.D.-level staff will provide support for the Center.

The Yale Chemical Instrumentation Center is a collection of instruments for molecular structure determination supervised by professional staff. The collection includes X-ray, NMR, mass spectroscopy, isothermal titration calorimetry, and optical spectroscopy facilities that are available on a walk-up and reservation basis.

MCDB hosts several advanced facilities for optical imaging. Among these is the Yale University Neuroengineering and Neuroscience Center (NNC), which provides advanced image acquisition and analysis services, using state of the art laser confocal microscopy in the ultraviolet and visible wavelengths. Among the instrumentation is a Biorad model 1024 UV laser confocal microscope system, configured with both UV argon ion laser and visible krypton argon lasers. The confocal microscope system allows for ratiometric measurements of ion levels in living tissues, as well as three-channel confocal microscopy of virtually all fluorophores currently available for biological research. The facility also houses advanced image processing workstations that are network linked to user laboratories.